Use of a HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation.

A HpaII-PCR assay was used to study DNA methylation in individual mouse embryos. It was found that HpaII site H-7 in the CpG island of the X-chromosome-linked Pgk-1 gene is less than or equal to 10% methylated in oocytes and male embryos but becomes 40% methylated in female embryos at 6.5 days; abou...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Singer-Sam, J, Grant, M, LeBon, J M, Okuyama, K, Chapman, V, Monk, M, Riggs, A D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361130/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1697035/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.9.4987-4989.1990
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