Mutations in the Nucleolar Phosphoprotein, Nucleophosmin, Promote the Expression of the Oncogenic Transcription Factor MEF/ELF4 in Leukemia Cells and Potentiates Transformation

Myeloid ELF1-like factor (MEF/ELF4), a member of the ETS transcription factors, can function as an oncogene in murine cancer models and is overexpressed in various human cancers. Here, we report a mechanism by which MEF/ELF4 may be activated by a common leukemia-associated mutation in the nucleophos...

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Hlavní autoři: Ando, Koji, Tsushima, Hideki, Matsuo, Emi, Horio, Kensuke, Tominaga-Sato, Shinya, Imanishi, Daisuke, Imaizumi, Yoshitaka, Iwanaga, Masako, Itonaga, Hidehiro, Yoshida, Shinichiro, Hata, Tomoko, Moriuchi, Ryozo, Kiyoi, Hitoshi, Nimer, Stephen, Mano, Hiroyuki, Naoe, Tomoki, Tomonaga, Masao, Miyazaki, Yasushi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3611015/
https://ncbi.nlm.nih.gov/pubmed/23393136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415703
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