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Inhibition of Neuronal Degenerin/Epithelial Na(+) Channels by the Multiple Sclerosis Drug 4-Aminopyridine
The voltage-gated K(+) (Kv) channel blocker 4-aminopyridine (4-AP) is used to target symptoms of the neuroinflammatory disease multiple sclerosis (MS). By blocking Kv channels, 4-AP facilitates action potential conduction and neurotransmitter release in presynaptic neurons, lessening the effects of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3611011/ https://ncbi.nlm.nih.gov/pubmed/23404498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.449413 |
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