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Inhibition of Neuronal Degenerin/Epithelial Na(+) Channels by the Multiple Sclerosis Drug 4-Aminopyridine

The voltage-gated K(+) (Kv) channel blocker 4-aminopyridine (4-AP) is used to target symptoms of the neuroinflammatory disease multiple sclerosis (MS). By blocking Kv channels, 4-AP facilitates action potential conduction and neurotransmitter release in presynaptic neurons, lessening the effects of...

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Detalles Bibliográficos
Main Authors: Boiko, Nina, Kucher, Volodymyr, Eaton, Benjamin A., Stockand, James D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3611011/
https://ncbi.nlm.nih.gov/pubmed/23404498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.449413
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