Lgr4 Gene Deficiency Increases Susceptibility and Severity of Dextran Sodium Sulfate-induced Inflammatory Bowel Disease in Mice

Lgr4/Gpr48 is one of the newly identified R-spondins receptors and potentiates Wnt signaling, which regulates intestinal homeostasis. We used a hypomorphic mouse strain to determine the role of Lgr4 in intestinal inflammation and recovery. Intestinal inflammation was induced with dextran sulfate sod...

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Hlavní autoři: Liu, Shijie, Qian, Yu, Li, Liang, Wei, Gaigai, Guan, Yuting, Pan, Hongjie, Guan, Xin, Zhang, Long, Lu, Xiaoling, Zhao, Yongxiang, Liu, Mingyao, Li, Dali
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610954/
https://ncbi.nlm.nih.gov/pubmed/23393138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.436204
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