Targeted Induction of Interferon-λ in Humanized Chimeric Mouse Liver Abrogates Hepatotropic Virus Infection

BACKGROUND & AIMS: The interferon (IFN) system plays a critical role in innate antiviral response. We presume that targeted induction of IFN in human liver shows robust antiviral effects on hepatitis C virus (HCV) and hepatitis B virus (HBV). METHODS: This study used chimeric mice harboring huma...

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Main Authors: Nakagawa, Shin-ichiro, Hirata, Yuichi, Kameyama, Takeshi, Tokunaga, Yuko, Nishito, Yasumasa, Hirabayashi, Kazuko, Yano, Junichi, Ochiya, Takahiro, Tateno, Chise, Tanaka, Yasuhito, Mizokami, Masashi, Tsukiyama-Kohara, Kyoko, Inoue, Kazuaki, Yoshiba, Makoto, Takaoka, Akinori, Kohara, Michinori
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610702/
https://ncbi.nlm.nih.gov/pubmed/23555725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059611
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