Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

Anti-tumor necrosis factor alpha (anti-TNF) biologic therapy is a widely used treatment for rheumatoid arthritis (RA). It is unknown why some RA patients fail to respond adequately to anti-TNF therapy, which limits the development of clinical biomarkers to predict response or new drugs to target ref...

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Main Authors: Cui, Jing, Stahl, Eli A., Saevarsdottir, Saedis, Miceli, Corinne, Diogo, Dorothee, Trynka, Gosia, Raj, Towfique, Mirkov, Maša Umiċeviċ, Canhao, Helena, Ikari, Katsunori, Terao, Chikashi, Okada, Yukinori, Wedrén, Sara, Askling, Johan, Yamanaka, Hisashi, Momohara, Shigeki, Taniguchi, Atsuo, Ohmura, Koichiro, Matsuda, Fumihiko, Mimori, Tsuneyo, Gupta, Namrata, Kuchroo, Manik, Morgan, Ann W., Isaacs, John D., Wilson, Anthony G., Hyrich, Kimme L., Herenius, Marieke, Doorenspleet, Marieke E., Tak, Paul-Peter, Crusius, J. Bart A., van der Horst-Bruinsma, Irene E., Wolbink, Gert Jan, van Riel, Piet L. C. M., van de Laar, Mart, Guchelaar, Henk-Jan, Shadick, Nancy A., Allaart, Cornelia F., Huizinga, Tom W. J., Toes, Rene E. M., Kimberly, Robert P., Bridges, S. Louis, Criswell, Lindsey A., Moreland, Larry W., Fonseca, João Eurico, de Vries, Niek, Stranger, Barbara E., De Jager, Philip L., Raychaudhuri, Soumya, Weinblatt, Michael E., Gregersen, Peter K., Mariette, Xavier, Barton, Anne, Padyukov, Leonid, Coenen, Marieke J. H., Karlson, Elizabeth W., Plenge, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610685/
https://ncbi.nlm.nih.gov/pubmed/23555300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003394
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