The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds

In this work, we investigated the effects of lowered oxygen tension (20% and 5% O(2)) on the chondrogenesis and hypertrophy of articular chondrocytes (ACs), mesenchymal stem cells (MSCs) and their co-cultures with a 30:70 AC:MSC ratio. Cells were cultured for six weeks within porous scaffolds, and t...

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Hauptverfasser: Meretoja, Ville V., Dahlin, Rebecca L., Wright, Sarah, Kasper, F. Kurtis, Mikos, Antonios G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610535/
https://ncbi.nlm.nih.gov/pubmed/23489925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2013.02.064
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