Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells

The mammalian target of rapamycin (mTOR) is a protein kinase that regulates protein translation, cell growth, and apoptosis. Rapamycin (RPM), a specific inhibitor of mTOR, exhibits potent and broad in vitro and in vivo antitumor activity against leukemia, breast cancer, and melanoma. Recent studies...

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Autori principali: Dai, Zhi-Jun, Gao, Jie, Kang, Hua-Feng, Ma, Yu-Guang, Ma, Xiao-Bin, Lu, Wang-Feng, Lin, Shuai, Ma, Hong-Bing, Wang, Xi-Jing, Wu, Wen-Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2013
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610438/
https://ncbi.nlm.nih.gov/pubmed/23662044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S42390
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