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Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
Genetic studies indicate that protein homeostasis is a major contributor to metazoan longevity(1). Collapse of protein homeostasis results in protein misfolding cascades and the accumulation of insoluble protein fibrils and aggregates, such as amyloids(2). A group of small molecules, traditionally u...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3610427/ https://ncbi.nlm.nih.gov/pubmed/21451522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09873 |
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