Copy Number Variation within Human β-Defensin Gene Cluster Influences Progression to AIDS in the Multicenter AIDS Cohort Study

STUDY BACKGROUND: DEFB4/103A encoding β-defensin 2 and 3, respectively, inhibit CXCR4-tropic (X4) viruses in vitro. We determined whether DEFB4/103A Copy Number Variation (CNV) influences time-to-X4 and time-to-AIDS outcomes. METHODS: We utilized samples from a previously published Multicenter AIDS...

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Main Authors: Mehlotra, Rajeev K., Dazard, Jean-Eudes, John, Bangan, Zimmerman, Peter A., Weinberg, Aaron, Jurevic, Richard J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610425/
https://ncbi.nlm.nih.gov/pubmed/23543857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2155-6113.1000184
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