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Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression

The causes of major depression remain unknown. Antidepressants elevate monoamine concentrations, particularly serotonin, but it remains uncertain which downstream events are critical to their therapeutic effects. We report that endogenous serotonin selectively potentiated excitatory synapses formed...

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Detalhes bibliográficos
Main Authors: Cai, Xiang, Kallarackal, Angy J., Kvarta, Mark D., Goluskin, Sasha, Gaylor, Kaitlin, Bailey, Aileen M., Lee, Hey-Kyoung, Huganir, Richard L., Thompson, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609911/
https://ncbi.nlm.nih.gov/pubmed/23502536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3355
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