Conditional Deletion of Jak2 Reveals an Essential Role in Hematopoiesis throughout Mouse Ontogeny: Implications for Jak2 Inhibition in Humans

Germline deletion of Jak2 in mice results in embryonic lethality at E12.5 due to impaired hematopoiesis. However, the role that Jak2 might play in late gestation and postnatal life is unknown. To understand this, we utilized a conditional knockout approach that allowed for the deletion of Jak2 at va...

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Detalhes bibliográficos
Main Authors: Park, Sung O., Wamsley, Heather L., Bae, Kyungmi, Hu, Zhongbo, Li, Xiaomiao, Choe, Se-woon, Slayton, William B., Oh, S. Paul, Wagner, Kay-Uwe, Sayeski, Peter P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609865/
https://ncbi.nlm.nih.gov/pubmed/23544085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059675
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