Constitutive Expression of Yes-Associated Protein (Yap) in Adult Skeletal Muscle Fibres Induces Muscle Atrophy and Myopathy

The aim of this study was to investigate the function of the Hippo pathway member Yes-associated protein (Yap, gene name Yap1) in skeletal muscle fibres in vivo. Specifically we bred an inducible, skeletal muscle fibre-specific knock-in mouse model (MCK-tTA-hYAP1 S127A) to test whether the over expr...

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Detalhes bibliográficos
Main Authors: Judson, Robert N., Gray, Stuart R., Walker, Claire, Carroll, Andrew M., Itzstein, Cecile, Lionikas, Arimantas, Zammit, Peter S., De Bari, Cosimo, Wackerhage, Henning
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609830/
https://ncbi.nlm.nih.gov/pubmed/23544078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059622
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