Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats

Chronic alcohol ingestion increases hepatic cytochrome P450 2E1 (CYP2E1), which is associated with hepatocarcinogenesis. We investigated whether treatment with chlormethiazole (CMZ), a CYP2E1 inhibitor, protects against alcohol-associated hepatic carcinogenesis in rats. Rats were fed either an ethan...

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Détails bibliographiques
Auteurs principaux: Ye, Qinyuan, Lian, Fuzhi, Chavez, Pollyanna R.G., Chung, Jayong, Ling, Wenhua, Qin, Hua, Seitz, Helmut K., Wang, Xiang-Dong
Format: Artigo
Langue:Inglês
Publié: AME Publishing Company 2012
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609654/
https://ncbi.nlm.nih.gov/pubmed/23543859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2304-3881.2012.11.05
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