Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.

The Fos-Jun complex has been shown to activate transcription through the regulatory element known as the AP-1 binding site. We show that Fos down regulates several immediate-early genes (c-fos, Egr-1, and Egr-2) after mitogenic stimulation. Specifically, we demonstrate that the target for this repre...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Biol
Autori principali: Gius, D, Cao, X M, Rauscher, F J, Cohen, D R, Curran, T, Sukhatme, V P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 1990
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360963/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2115122/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.8.4243
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