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Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGFβR1

Lipoxins, which are endogenously produced lipid mediators, promote the resolution of inflammation, and may inhibit fibrosis, suggesting a possible role in modulating renal disease. Here, lipoxin A4 (LXA(4)) attenuated TGF-β1–induced expression of fibronectin, N-cadherin, thrombospondin, and the notc...

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Detalhes bibliográficos
Main Authors: Brennan, Eoin P., Nolan, Karen A., Börgeson, Emma, Gough, Oisín S., McEvoy, Caitríona M., Docherty, Neil G., Higgins, Debra F., Murphy, Madeline, Sadlier, Denise M., Ali-Shah, Syed Tasadaque, Guiry, Patrick J., Savage, David A., Maxwell, Alexander P., Martin, Finian, Godson, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609134/
https://ncbi.nlm.nih.gov/pubmed/23520204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012060550
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