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Silencing synapses: A route to understanding synapse degeneration in chronic neurodegenerative disease

The degeneration of pre-synaptic boutons in the stratum radiatum of the dorsal hippocampus is one of earliest components of neurodegeneration in several models of murine prion disease. We recently showed that blockade of synaptic transmission by infusion of botulinum neurotoxin A (BoNT/A) into the h...

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Detalhes bibliográficos
Main Authors: Caleo, Matteo, Restani, Laura, Perry, V. Hugh
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609122/
https://ncbi.nlm.nih.gov/pubmed/23357830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.23327
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