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Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding
The recently discovered 150-cavity (formed by loop residues 147–152, N2 numbering) adjacent to the enzymatic active site of group 1 influenza A neuraminidase (NA) has introduced a novel target for the design of next-generation NA inhibitors. However, only group 1 NAs, with the exception of the 2009...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3609017/ https://ncbi.nlm.nih.gov/pubmed/23531861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01551 |
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