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Blockade of SOX4 mediated DNA repair by SPARC enhances radioresponse in medulloblastoma
SPARC is a matricellular glycoprotein and a putative radioresistance-reversal-gene. We therefore explored the possibility of SPARC expression on medulloblastoma radiosensitivity in vitro and in vivo. The combined treatment of the SPARC and irradiation resulted in increased cell death when compared t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608856/ https://ncbi.nlm.nih.gov/pubmed/22542805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.04.014 |
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