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Generation of human induced pluripotent stem cells to model spinocerebellar ataxia type 2 in vitro
Spinocerebellar ataxia type 2 (SCA 2) is caused by triple nucleotide repeat (CAG) expansion in the coding region of the ATAXN2 gene on chromosome 12, which produces an elongated, toxic polyglutamine tract, leading to Purkinje cell loss. There is currently no effective therapy. One of the main obstac...
Tallennettuna:
| Päätekijät: | , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608734/ https://ncbi.nlm.nih.gov/pubmed/23224816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-012-9930-2 |
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