A Broad Profile of Co-Dominant Epitopes Shapes the Peripheral Mycobacterium tuberculosis Specific CD8+ T-Cell Immune Response in South African Patients with Active Tuberculosis

We studied major histocompatibility complex (MHC) class I peptide-presentation and nature of the antigen-specific CD8+ T-cell response from South African tuberculosis (TB) patients with active TB. 361 MHC class I binding epitopes were identified from three immunogenic TB proteins (ESAT-6 [Rv3875], A...

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Bibliographic Details
Main Authors: Axelsson-Robertson, Rebecca, Loxton, André G., Walzl, Gerhard, Ehlers, Marthie M., Kock, Marleen M., Zumla, Alimuddin, Maeurer, Markus
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608651/
https://ncbi.nlm.nih.gov/pubmed/23555576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058309
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