Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

Three-dimensional (3D) tumor cell cultures grown in laminin-rich-extracellular matrix (lrECM) are considered to reflect human tumors more realistic as compared to cells grown as monolayer on plastic. Here, we systematically investigated the impact of ECM on phenotype, gene expression, EGFR signaling...

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Detalhes bibliográficos
Main Authors: Luca, Anna C., Mersch, Sabrina, Deenen, René, Schmidt, Stephan, Messner, Isabelle, Schäfer, Karl-Ludwig, Baldus, Stephan E., Huckenbeck, Wolfgang, Piekorz, Roland P., Knoefel, Wolfram T., Krieg, Andreas, Stoecklein, Nikolas H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608563/
https://ncbi.nlm.nih.gov/pubmed/23555746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059689
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