Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

Three-dimensional (3D) tumor cell cultures grown in laminin-rich-extracellular matrix (lrECM) are considered to reflect human tumors more realistic as compared to cells grown as monolayer on plastic. Here, we systematically investigated the impact of ECM on phenotype, gene expression, EGFR signaling...

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Main Authors: Luca, Anna C., Mersch, Sabrina, Deenen, René, Schmidt, Stephan, Messner, Isabelle, Schäfer, Karl-Ludwig, Baldus, Stephan E., Huckenbeck, Wolfgang, Piekorz, Roland P., Knoefel, Wolfram T., Krieg, Andreas, Stoecklein, Nikolas H.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608563/
https://ncbi.nlm.nih.gov/pubmed/23555746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059689
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