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Total synthesis of (−)-dihydroprotolichesterenic acid via diastereoselective conjugate addition to chiral fumarates
A diastereoselective conjugate addition of a variety of monoorganocuprates, Li[RCuI], to chiral fumarates to provide funtionalized succinates has been developed. The utility of this reaction is demonstrated in a concise total synthesis of (−)-dihydroprotolichesterenic acid that required only four st...
Αποθηκεύτηκε σε:
Κύριοι συγγραφείς: | , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
2013
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3607549/ https://ncbi.nlm.nih.gov/pubmed/23539490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2013.02.014 |
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