Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by trinucleotide repeat (TNR) expansions. We show here that somatic TNR expansions are significantly reduced in several organs of R6/1 mice lacking exon 2 of Nei-like 1 (Neil1) (R6/1/Neil1(−/−)), when compared with R6/...

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Detalhes bibliográficos
Main Authors: Møllersen, Linda, Rowe, Alexander D., Illuzzi, Jennifer L., Hildrestrand, Gunn A., Gerhold, Katharina J., Tveterås, Linda, Bjølgerud, Anja, Wilson, David M., Bjørås, Magnar, Klungland, Arne
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607484/
https://ncbi.nlm.nih.gov/pubmed/22914735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds337
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