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A Simple Approach to Assign Disulfide Connectivity Using Extracted Ion Chromatograms of Electron Transfer Dissociation Spectra

Increasing interest in production of protein-based pharmaceuticals (biotherapeutics) is accompanied by an increased need for verification of protein folding and correct disulfide bonding. Recombinant protein expression may produce aberrant disulfide bonds and could result in safety concerns or decre...

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Bibliografiska uppgifter
Huvudupphovsmän: Clark, Daniel F, Go, Eden P, Desaire, Heather
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607449/
https://ncbi.nlm.nih.gov/pubmed/23210856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac303124w
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