PRAME expression in head and neck cancer correlates with markers of poor prognosis and might help in selecting candidates for retinoid chemoprevention in pre-malignant lesions

OBJECTIVES: PRAME (Preferentially Expressed Antigen in Melanoma) is a tumor-associated antigen recognized by immunocytes, and it induces cytotoxic T cell-mediated responses in melanoma. PRAME expression in tumors interferes with retinoic acid receptor (RAR) signaling thus promoting tumor progression...

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Hauptverfasser: Szczepanski, Miroslaw J., DeLeo, Albert B., Łuczak, Michał, Molinska-Glura, Marta, Misiak, Jan, Szarzynska, Bronislawa, Dworacki, Grzegorz, Zagor, Mariola, Rozwadowska, Natalia, Kurpisz, Maciej, Krzeski, Antoni, Kruk-Zagajewska, Aleksandra, Kopec, Tomasz, Banaszewski, Jacek, Whiteside, Theresa L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607432/
https://ncbi.nlm.nih.gov/pubmed/22944049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2012.08.005
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