Preparation, characterization, and in vitro and in vivo investigation of chitosan-coated poly (d,l-lactide-co-glycolide) nanoparticles for intestinal delivery of exendin-4

BACKGROUND: Exendin-4 is an incretin mimetic agent approved for type 2 diabetes treatment. However, the required frequent injections restrict its clinical application. Here, the potential use of chitosan-coated poly (d,l-lactide-co-glycolide) (CS-PLGA) nanoparticles was investigated for intestinal d...

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Detalhes bibliográficos
Main Authors: Wang, Mengshu, Zhang, Yong, Feng, Jiao, Gu, Tiejun, Dong, Qingguang, Yang, Xu, Sun, Yanan, Wu, Yongge, Chen, Yan, Kong, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607418/
https://ncbi.nlm.nih.gov/pubmed/23658482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S41457
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