PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

Hypoxia is a common feature of tumors and an important contributor to malignancy and treatment resistance. The ability of tumor cells to survive hypoxic stress is mediated in part by hypoxia-inducible factor (HIF)-dependent transcriptional responses. More severe hypoxia activates endoplasmatic retic...

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Main Authors: Rouschop, Kasper M., Dubois, Ludwig J., Keulers, Tom G., van den Beucken, Twan, Lambin, Philippe, Bussink, Johan, van der Kogel, Albert J., Koritzinsky, Marianne, Wouters, Bradly G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2013
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607059/
https://ncbi.nlm.nih.gov/pubmed/23471998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210633110
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