Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review

Double-hit or triple-hit B-cell lymphomas (DHL and THL) are rare subtype lymphomas usually associated with poor prognosis. It is defined by two or three recurrent chromosome translocations; MYC/8q24 loci, usually in combination with the t (14; 18) (q32; q21) bcl-2 gene or/and BCL6/3q27 chromosomal t...

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Main Authors: Xu, Xiaoxiao, Zhang, Le, Wang, Yafei, Zhang, Qing, Zhang, Lianyu, Sun, Baocun, Zhang, Yizhuo
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2013
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606871/
https://ncbi.nlm.nih.gov/pubmed/23573328
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spelling pubmed-36068712013-04-09 Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review Xu, Xiaoxiao Zhang, Le Wang, Yafei Zhang, Qing Zhang, Lianyu Sun, Baocun Zhang, Yizhuo Int J Clin Exp Pathol Case Report Double-hit or triple-hit B-cell lymphomas (DHL and THL) are rare subtype lymphomas usually associated with poor prognosis. It is defined by two or three recurrent chromosome translocations; MYC/8q24 loci, usually in combination with the t (14; 18) (q32; q21) bcl-2 gene or/and BCL6/3q27 chromosomal translocation. DHL was often observed both in de-novo diffuse large B cell lymphomas (DLBCL). It is otherwise unclassifiable, showing features intermediate that of large B-cell lymphoma and Burkitt lymphoma. Here, we present two follicular lymphoma patients; one transformed to THL, another transformed to DHL. Both cases revealed aggressive clinical courses with poor prognosis and associated with acquisition of c-Myc gene (MYC) and central nervous system (CNS) involvement. We reviewed the related literature, correlated the immunophenotype and clinical manifestations such as response to therapy and prognosis. Although the incidence of DHT and THL is low, cytogenetic and FISH analyses should be included when B-cell lymphoma patients experience relapse or refractory course of disease. We concluded that c-Myc may contribute to aggressive transformation, and more mechanism-based therapy should be explored. e-Century Publishing Corporation 2013-03-15 /pmc/articles/PMC3606871/ /pubmed/23573328 Text en IJCEP Copyright © 2013
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Case Report
spellingShingle Case Report
Xu, Xiaoxiao
Zhang, Le
Wang, Yafei
Zhang, Qing
Zhang, Lianyu
Sun, Baocun
Zhang, Yizhuo
Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review
description Double-hit or triple-hit B-cell lymphomas (DHL and THL) are rare subtype lymphomas usually associated with poor prognosis. It is defined by two or three recurrent chromosome translocations; MYC/8q24 loci, usually in combination with the t (14; 18) (q32; q21) bcl-2 gene or/and BCL6/3q27 chromosomal translocation. DHL was often observed both in de-novo diffuse large B cell lymphomas (DLBCL). It is otherwise unclassifiable, showing features intermediate that of large B-cell lymphoma and Burkitt lymphoma. Here, we present two follicular lymphoma patients; one transformed to THL, another transformed to DHL. Both cases revealed aggressive clinical courses with poor prognosis and associated with acquisition of c-Myc gene (MYC) and central nervous system (CNS) involvement. We reviewed the related literature, correlated the immunophenotype and clinical manifestations such as response to therapy and prognosis. Although the incidence of DHT and THL is low, cytogenetic and FISH analyses should be included when B-cell lymphoma patients experience relapse or refractory course of disease. We concluded that c-Myc may contribute to aggressive transformation, and more mechanism-based therapy should be explored.
author Xu, Xiaoxiao
Zhang, Le
Wang, Yafei
Zhang, Qing
Zhang, Lianyu
Sun, Baocun
Zhang, Yizhuo
author_facet Xu, Xiaoxiao
Zhang, Le
Wang, Yafei
Zhang, Qing
Zhang, Lianyu
Sun, Baocun
Zhang, Yizhuo
author_sort Xu, Xiaoxiao
title Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review
title_short Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review
title_full Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review
title_fullStr Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review
title_full_unstemmed Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review
title_sort double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of myc: report of two cases and literature review
publisher e-Century Publishing Corporation
publishDate 2013
url https://ncbi.nlm.nih.gov/pmc/articles/PMC3606871/
https://ncbi.nlm.nih.gov/pubmed/23573328
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