Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase.

We have isolated cDNA clones representing cyclic AMP (cAMP)-specific phosphodiesterases (PDEases) from a human monocyte cDNA library. One cDNA clone (hPDE-1) defines a large open reading frame of ca. 2.1 kilobases, predicting a 686-amino-acid, ca. 77-kilodalton protein which contains significant hom...

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Auteurs principaux: Livi, G P, Kmetz, P, McHale, M M, Cieslinski, L B, Sathe, G M, Taylor, D P, Davis, R L, Torphy, T J, Balcarek, J M
Format: Artigo
Langue:Inglês
Publié: 1990
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC360627/
https://ncbi.nlm.nih.gov/pubmed/2160582
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