Mutational activation of c-raf-1 and definition of the minimal transforming sequence.

A series of wild-type and mutant raf genes was transfected into NIH 3T3 cells and analyzed for transforming activity. Full-length wild-type c-raf did not show transforming activity. Two types of mutations resulted in oncogenic activity similar to that of v-raf: truncation of the amino-terminal half...

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Bibliografiske detaljer
Main Authors: Heidecker, G, Huleihel, M, Cleveland, J L, Kolch, W, Beck, T W, Lloyd, P, Pawson, T, Rapp, U R
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC360607/
https://ncbi.nlm.nih.gov/pubmed/2188091
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