Mutational activation of c-raf-1 and definition of the minimal transforming sequence.

A series of wild-type and mutant raf genes was transfected into NIH 3T3 cells and analyzed for transforming activity. Full-length wild-type c-raf did not show transforming activity. Two types of mutations resulted in oncogenic activity similar to that of v-raf: truncation of the amino-terminal half...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Heidecker, G, Huleihel, M, Cleveland, J L, Kolch, W, Beck, T W, Lloyd, P, Pawson, T, Rapp, U R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360607/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2188091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.6.2503-2512.1990
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