Targeted delivery of doxorubicin through conjugation with EGF receptor–binding peptide overcomes drug resistance in human colon cancer cells

BACKGROUND AND PURPOSE: Induction of multidrug resistance by doxorubicin (DOX), together with non-specific toxicities, has restricted DOX-based chemotherapy. Recently, we demonstrated that DOX conjugated with an EGF receptor-binding peptide (DOX-EBP) had enhanced anticancer efficacy and reduced syst...

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Detalhes bibliográficos
Main Authors: Ai, Shibin, Jia, Tao, Ai, Weilun, Duan, Jianli, Liu, Yongmei, Chen, Jing, Liu, Xin, Yang, Fan, Tian, Yuan, Huang, Zebo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605878/
https://ncbi.nlm.nih.gov/pubmed/23146125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12055
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