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TRPM2 links oxidative stress to the NLRP3 inflammasome activation
Exposure to particulate crystals can induce oxidative stress in phagocytes, which triggers NLRP3 inflammasome-mediated interleukin 1β (IL-1β) secretion to initiate undesirable inflammatory responses that are associated with both autoinflammatory and metabolic diseases. Although mitochondrial reactiv...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3605705/ https://ncbi.nlm.nih.gov/pubmed/23511475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2608 |
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