Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)

Pentameric ligand-gated ion channels (pLGICs), such as nicotinic acetylcholine, glycine, γ-aminobutyric acid GABA(A/C) receptors, and the Gloeobacter violaceus ligand-gated ion channel (GLIC), are receptors that contain multiple allosteric binding sites for a variety of therapeutics, including gener...

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Autores principales: Spurny, Radovan, Billen, Bert, Howard, Rebecca J., Brams, Marijke, Debaveye, Sarah, Price, Kerry L., Weston, David A., Strelkov, Sergei V., Tytgat, Jan, Bertrand, Sonia, Bertrand, Daniel, Lummis, Sarah C. R., Ulens, Chris
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605653/
https://ncbi.nlm.nih.gov/pubmed/23364792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424507
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