Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis

Patients with hemophagocytic lymphohistiocytosis (HLH) exhibit immune hyper-activation as a consequence of genetic defects in secretory granule proteins of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Murine models of HLH demonstrate significant activation of CTL as central to the di...

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Detalhes bibliográficos
Main Authors: Mellor-Heineke, Sabine, Villanueva, Joyce, Jordan, Michael B., Marsh, Rebecca, Zhang, Kejian, Bleesing, Jack J., Filipovich, Alexandra H., Risma, Kimberly A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605512/
https://ncbi.nlm.nih.gov/pubmed/23524976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00072
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