Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

The protein kinase GCN2 stimulates expression of the yeast transcriptional activator GCN4 at the translational level by phosphorylating the alpha subunit of translation initiation factor 2 (eIF-2 alpha) in amino acid-starved cells. Phosphorylation of eIF-2 alpha reduces its activity, allowing riboso...

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Bibliographic Details
Main Authors: Ramirez, M, Wek, R C, Vazquez de Aldana, C R, Jackson, B M, Freeman, B, Hinnebusch, A G
Format: Artigo
Language:Inglês
Published: 1992
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC360520/
https://ncbi.nlm.nih.gov/pubmed/1448107
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