High Mobility Group Box–1 Mediates Hyperoxia-Induced Impairment of Pseudomonas aeruginosa Clearance and Inflammatory Lung Injury in Mice

Mechanical ventilation with supraphysiological concentrations of oxygen (hyperoxia) is routinely used to treat patients with respiratory distress. However, a significant number of patients on ventilators exhibit enhanced susceptibility to infections and develop ventilator-associated pneumonia (VAP)....

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Hlavní autoři: Patel, Vivek S., Sitapara, Ravikumar A., Gore, Ashwini, Phan, Binh, Sharma, Lokesh, Sampat, Vaishali, Li, Jian Hua, Yang, Huan, Chavan, Sangeeta S., Wang, Haichao, Tracey, Kevin J., Mantell, Lin L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604087/
https://ncbi.nlm.nih.gov/pubmed/23087050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0279OC
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