Pharmacokinetic–Pharmacodynamic Modeling of Severity Levels of Extrapyramidal Side Effects With Markov Elements

A major problem in the treatment of schizophrenic patients with current antipsychotic drugs, mainly acting as dopamine-2 receptor antagonists, is the occurrence of side effects such as extrapyramidal symptoms (EPS). Meta-analyses of summary data of EPS occurrence, and receptor occupancies inferred f...

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Autori principali: Pilla Reddy, V, Petersson, K J, Suleiman, A A, Vermeulen, A, Proost, J H, Friberg, L E
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603470/
https://ncbi.nlm.nih.gov/pubmed/23835881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.9
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