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Spontaneous autoimmunity in the absence of IL-2 is driven by uncontrolled dendritic cells
BALB/c IL-2-deficient (IL-2-KO) mice develop systemic autoimmunity, dying within 3 to 5 weeks from complications of autoimmune hemolytic anemia. Disease in these mice is Th1-mediated, and IFNγ production is required for early autoimmunity. In this study we show that dendritic cells (DC) are required...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3603347/ https://ncbi.nlm.nih.gov/pubmed/22778392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200342 |
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