Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

BACKGROUND: The mechanisms by which ischemic preconditioning (IP) inhibits mitochondrial permeability transition pore opening and, hence, ischemia–reperfusion injury remain unclear. Here we investigate whether and how mitochondria‐bound hexokinase 2 (mtHK2) may exert part of the cardioprotective eff...

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Autors principals: Pasdois, Philippe, Parker, Joanne Elizabeth, Halestrap, Andrew Philip
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603240/
https://ncbi.nlm.nih.gov/pubmed/23525412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.005645
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