EGF-Receptor Phosphorylation and Downstream Signaling are Activated by Benzo[a]pyrene 3,6-quinone and Benzo[a]pyrene 1,6-quinone in Human Mammary Epithelial Cells

Benzo[a]pyrene (BaP) is activated by xenobiotic-metabolizing enzymes to highly mutagenic and carcinogenic metabolites. Previous studies in this laboratory have shown that benzo(a)pyrene quinones (BPQs), 1,6-BPQ and 3,6-BPQ, are able to induce epidermal growth factor receptor (EGFR) cell signaling th...

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Hlavní autoři: Rodríguez-Fragoso, Lourdes, Melendez, Karla, Hudson, Laurie, Lauer, Fredine T., Burchiel, Scott W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602997/
https://ncbi.nlm.nih.gov/pubmed/19166869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2008.12.022
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