SOCS3 promotor hypermethylation and STAT3-NF-κB interaction downregulate SOCS3 expression in human coronary artery smooth muscle cells

Suppressor of cytokine signaling-3 (SOCS3) is an intracellular negative regulator of cytokine signaling pathway. We recently found significant reduction in SOCS3 expression in coronary artery smooth muscle cells (CASMCs) of atherosclerotic swine and also in vitro cultured cells. Here, we investigate...

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Bibliografiska uppgifter
Huvudupphovsmän: Dhar, Kajari, Rakesh, Kriti, Pankajakshan, Divya, Agrawal, Devendra K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2013
Ämnen:
Vascular Biology and Microcirculation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602771/
https://ncbi.nlm.nih.gov/pubmed/23335796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00570.2012
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