Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats

Fructose in sweetened beverages (SB) increases the risk for metabolic and cardiorenal disorders, and these effects are in part mediated by a secondary increment in uric acid (UA). Rodents have an active uricase, thus requiring large doses of fructose to increase plasma UA and to induce metabolic syn...

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Main Authors: Tapia, Edilia, Cristóbal, Magdalena, García-Arroyo, Fernando E., Soto, Virgilia, Monroy-Sánchez, Fabiola, Pacheco, Ursino, Lanaspa, Miguel A., Roncal-Jiménez, Carlos A., Cruz-Robles, David, Ishimoto, Takuji, Madero, Magdalena, Johnson, Richard J., Sánchez-Lozada, Laura-Gabriela
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602695/
https://ncbi.nlm.nih.gov/pubmed/23303409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00485.2012
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