Dexamethasone-Mediated Changes in Adipose Triacylglycerol Metabolism Are Exaggerated, Not Diminished, in the Absence of a Functional GR Dimerization Domain

The glucocorticoid (GC) receptor (GR) has multiple effector mechanisms, including dimerization-mediated transactivation of target genes via DNA binding and transcriptional repression mediated by protein-protein interactions. Much attention has been focused on developing selective GR modulators that...

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Bibliographic Details
Main Authors: Roohk, Donald J., Mascharak, Smita, Khambatta, Cyrus, Leung, Ho, Hellerstein, Marc, Harris, Charles
Format: Artigo
Language:Inglês
Published: Endocrine Society 2013
Subjects:
Glucocorticoids-CRH-ACTH-Adrenal
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602623/
https://ncbi.nlm.nih.gov/pubmed/23493372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1047
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