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Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.

The DNA binding activity of the c-jun proto-oncogene product is inhibited by oxidation of a specific cysteine residue (Cys-252) in the DNA binding domain. Jun protein inactivated by oxidation of this residue can be efficiently reactivated by a factor from human cell nuclei, recently identified as a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Walker, L J, Robson, C N, Black, E, Gillespie, D, Hickson, I D
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1993
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC360239/
https://ncbi.nlm.nih.gov/pubmed/8355688
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