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Semisynthetic Studies Identify Mitochondria Poisons from Botanical Dietary Supplements – Geranyloxycoumarins from Aegle marmelos

Bioassay-guided isolation and subsequent structure elucidation of a Bael tree Aegle marmelos lipid extract yielded two unstable acylated geranyloxycoumarin mixtures (1–2), six geranyloxycoumarins (3–8), (+)-9′-isovaleroxylariciresinol (9), and dehydromarmeline (10). In a T47D cell-based reporter ass...

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Autors principals: Li, Jun, Mahdi, Fakhri, Du, Lin, Jekabsons, Mika B., Zhou, Yu-Dong, Nagle, Dale G.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602229/
https://ncbi.nlm.nih.gov/pubmed/23434131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.01.048
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