Hepatocyte growth factor sensitizes brain tumors to c-MET kinase inhibition

PURPOSE: The receptor tyrosine kinase (RTK) c-MET and its ligand hepatocyte growth factor (HGF) are deregulated and promote malignancy in cancer and brain tumors. Consequently, clinically applicable c-MET inhibitors have been developed. The purpose of this study was to investigate the not well known...

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Autori principali: Zhang, Ying, Farenholtz, Kaitlyn E., Yang, Yanzhi, Guessous, Fadila, diPierro, Charles G., Calvert, Valerie S., Deng, Jianghong, Schiff, David, Xin, Wenjun, Lee, Jae K., Purow, Benjamin, Christensen, James, Petricoin, Emanuel, Abounader, Roger
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602223/
https://ncbi.nlm.nih.gov/pubmed/23386689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2832
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