Cytomegalovirus-induced salivary gland pathology: resistance to kinase inhibitors of the upregulated host cell EGFR/ERK pathway is associated with CMV-dependent stromal overexpression of IL-6 and fibronectin

BACKGROUND: Recently we identified a relationship between human cytomegalovirus (hCMV) and human salivary gland (SG) mucoepidermoid carcinoma (MEC) in over 90% of cases; tumorigenesis in these cases uniformly correlated with active hCMV protein expression and an upregulation of the EGFR → ERK pathwa...

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Autori principali: Melnick, Michael, Sedghizadeh, Parish P, Deluca, Krysta A, Jaskoll, Tina
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602079/
https://ncbi.nlm.nih.gov/pubmed/23342981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2042-4280-4-1
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