Molecular Modeling of Disease Causing Mutations in Domain C1 of cMyBP-C

Cardiac myosin binding protein-C (cMyBP-C) is a multi-domain (C0–C10) protein that regulates heart muscle contraction through interaction with myosin, actin and other sarcomeric proteins. Several mutations of this protein cause familial hypertrophic cardiomyopathy (HCM). Domain C1 of cMyBP-C plays a...

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Detalhes bibliográficos
Main Authors: Gajendrarao, Poornima, Krishnamoorthy, Navaneethakrishnan, Kassem, Heba Sh, Moharem-Elgamal, Sarah, Cecchi, Franco, Olivotto, Iacopo, Yacoub, Magdi H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602012/
https://ncbi.nlm.nih.gov/pubmed/23527136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059206
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