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Memantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot study

OBJECTIVE: Preclinical data suggests that memantine, a noncompetitive glutamate N-methyl-D-aspartate (NMDA)-receptor blocker used for the treatment of moderate to severe Alzheimer’s disease, could reduce depressive and amotivated behavior occurring in the context of psychosocial stress. Therefore we...

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Bibliographic Details
Main Authors: Lenze, Eric J., Skidmore, Elizabeth R., Begley, Amy E., Newcomer, John W., Butters, Meryl A., Whyte, Ellen M.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601891/
https://ncbi.nlm.nih.gov/pubmed/22173933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gps.2813
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